Contact your doctor if you notice white patches in your mouth, a change in vaginal discharge or other new symptoms. A very serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs.
Symptoms of a serious allergic reaction may include: The amoxicillin in this combination medication can commonly cause a mild rash that is usually not serious. However, you may not be able to tell it apart from a rare rash that could be a sign of a severe allergic reaction.
Therefore, seek immediate medical attention if you develop any rash. This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist. In the US -Call your doctor for medical advice about side effects. In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at Quick GuideSymptoms of Mono: This medication should not be used if you have certain medical conditions.
Before using this medicine, consult your doctor or pharmacist if you have: Before using this medication, tell your doctor or pharmacist your medical history, especially of: Kidney function declines as you grow older.
This medication is removed by the kidneys. Therefore, elderly people may be more sensitive to this drug. This medication should be used only when clearly needed during pregnancy. This rash is not necessarily indicative of a lifelong amoxicillin hypersensitivity. Rare cases of jaundice, ductopenia, cholestatic hepatitis, granulomatous hepatitis, hepatic necrosis, and hepatocellular damage have also been reported. Less than 1 death per approximately 4 million prescriptions has been reported worldwide.
Hepatic cholestasis and acute cytolytic hepatitis have been reported with amoxicillin use. However, hepatocellular and mixed-type cholestatic and hepatocellular injury have also been documented. In many instances, hepatotoxicity may be due to a hypersensitivity. Onset of symptoms has been delayed in some patients, with presentation occurring after therapy has been discontinued. Prolonged treatment may increase the risk of hepatotoxicity. Elderly patients may be at increased risk of developing amoxicillin-clavulanate-induced jaundice.
Fatalities are rare, but have been reported. Rechallenge with amoxicillin alone has not been followed by a recurrence of hepatitis. However, rechallenge with amoxicillin-clavulanate has resulted in a relapse of liver injury. Therefore, the clavulanic acid may be the hepatotoxic part of the drug. In patients with liver disease , frequent monitoring of liver function tests during amoxicillin-clavulanate therapy is recommended.
In general, Streptococcus , Bacillus subtilis , Enterococcus , Haemophilus , Helicobacter , and Moraxella are susceptible to amoxicillin, whereas Citrobacter , Klebsiella and Pseudomonas aeruginosa are resistant to it. Loose bowel movements diarrhea may also occur.
Rarer side effects include mental changes, lightheadedness, insomnia, confusion, anxiety, sensitivity to lights and sounds, and unclear thinking. Immediate medical care is required upon the first signs of these side effects.
The onset of an allergic reaction to amoxicillin can be very sudden and intense; emergency medical attention must be sought as quickly as possible. The initial phase of such a reaction often starts with a change in mental state, skin rash with intense itching often beginning in fingertips and around groin area and rapidly spreading , and sensations of fever, nausea, and vomiting. Any other symptoms that seem even remotely suspicious must be taken very seriously.
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